Package: DTAT 0.3-7

DTAT: Dose Titration Algorithm Tuning

Dose Titration Algorithm Tuning (DTAT) is a methodologic framework allowing dose individualization to be conceived as a continuous learning process that begins in early-phase clinical trials and continues throughout drug development, on into clinical practice. This package includes code that researchers may use to reproduce or extend key results of the DTAT research programme, plus tools for trialists to design and simulate a '3+3/PC' dose-finding study. Please see Norris (2017a) <doi:10.12688/f1000research.10624.3> and Norris (2017c) <doi:10.1101/240846>.

Authors:David C. Norris [aut, cre]

DTAT_0.3-7.tar.gz
DTAT_0.3-7.zip(r-4.5)DTAT_0.3-7.zip(r-4.4)DTAT_0.3-7.zip(r-4.3)
DTAT_0.3-7.tgz(r-4.4-any)DTAT_0.3-7.tgz(r-4.3-any)
DTAT_0.3-7.tar.gz(r-4.5-noble)DTAT_0.3-7.tar.gz(r-4.4-noble)
DTAT_0.3-7.tgz(r-4.4-emscripten)DTAT_0.3-7.tgz(r-4.3-emscripten)
DTAT.pdf |DTAT.html
DTAT/json (API)

# Install 'DTAT' in R:
install.packages('DTAT', repos = c('https://dcnorris.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Datasets:
  • de.bioRxiv.240846 - Simulated '3+3/PC' dose-titration study from bioRxiv paper no. 240846
  • dtat1000 - Precomputed neutrophil-guided chemotherapy dose titration for 1000 simulated subjects.

On CRAN:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

11 exports 0.82 score 84 dependencies 2 mentions 20 scripts 330 downloads

Last updated 4 months agofrom:15c3359875. Checks:OK: 1 WARNING: 6. Indexed: yes.

TargetResultDate
Doc / VignettesOKAug 23 2024
R-4.5-winWARNINGAug 23 2024
R-4.5-linuxWARNINGAug 23 2024
R-4.4-winWARNINGAug 23 2024
R-4.4-macWARNINGAug 23 2024
R-4.3-winWARNINGAug 23 2024
R-4.3-macWARNINGAug 23 2024

Exports:as_d3_datadose.survfitdose.survivalds.curvenewton.raphsonOnoue.FribergplotrunDTATappsimtitratetitration

Dependencies:backportsbase64encbslibcachemcheckmatecliclustercodacolorspacecommonmarkcrayondata.tabledeSolvedigestdplyrevaluatefansifarverfastmapfontawesomeforeignFormulafsgenericsggplot2gluegridExtragtablehighrHmischtmlTablehtmltoolshtmlwidgetshttpuvisobandjquerylibjsonlitekm.ciknitrlabelinglaterlatticelifecyclemagrittrMASSMatrixmemoisemgcvmimemunsellmvtnormnlmennetpillarpkgconfigpomppromisesr2d3R6rappdirsRColorBrewerRcpprlangrmarkdownrpartrstudioapisassscalesshinysourcetoolsstringistringrsurvivaltibbletidyselecttinytexutf8vctrsviridisviridisLitewithrxfunxtableyaml

Code and figures for 'DTAT should supersede MTD' v1

Rendered fromdtat.Rmdusingknitr::rmarkdownon Aug 23 2024.

Last update: 2023-03-29
Started: 2023-03-29

Designing a 3+3/PC trial

Rendered fromDesigning-33PC.Rmdusingknitr::rmarkdownon Aug 23 2024.

Last update: 2020-06-14
Started: 2019-02-18