Package: DTAT 0.3-8

DTAT: Dose Titration Algorithm Tuning

Dose Titration Algorithm Tuning (DTAT) is a methodologic framework allowing dose individualization to be conceived as a continuous learning process that begins in early-phase clinical trials and continues throughout drug development, on into clinical practice. This package includes code that researchers may use to reproduce or extend key results of the DTAT research programme, plus tools for trialists to design and simulate a '3+3/PC' dose-finding study. Please see Norris (2017a) <doi:10.12688/f1000research.10624.3> and Norris (2017c) <doi:10.1101/240846>.

Authors:David C. Norris [aut, cre]

DTAT_0.3-8.tar.gz
DTAT_0.3-8.zip(r-4.7)DTAT_0.3-8.zip(r-4.6)DTAT_0.3-8.zip(r-4.5)
DTAT_0.3-8.tgz(r-4.6-any)DTAT_0.3-8.tgz(r-4.5-any)
DTAT_0.3-8.tar.gz(r-4.7-any)DTAT_0.3-8.tar.gz(r-4.6-any)
DTAT_0.3-8.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
card.svg |card.png
DTAT/json (API)

# Install 'DTAT' in R:
install.packages('DTAT', repos = c('https://dcnorris.r-universe.dev', 'https://cloud.r-project.org'))
Datasets:
  • de.bioRxiv.240846 - Simulated '3+3/PC' dose-titration study from bioRxiv paper no. 240846
  • dtat1000 - Precomputed neutrophil-guided chemotherapy dose titration for 1000 simulated subjects.

On CRAN:

Conda:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

2.90 score 20 scripts 297 downloads 2 mentions 11 exports 80 dependencies

Last updated from:7f60dd902f. Checks:7 WARNING, 2 OK. Indexed: yes.

TargetResultTimeFilesSyslog
linux-devel-x86_64WARNING190
source / vignettesOK224
linux-release-x86_64WARNING195
macos-release-arm64WARNING191
macos-oldrel-arm64WARNING214
windows-develWARNING296
windows-releaseWARNING131
windows-oldrelWARNING213
wasm-releaseOK150

Exports:as_d3_datadose.survfitdose.survivalds.curvenewton.raphsonOnoue.FribergplotrunDTATappsimtitratetitration

Dependencies:backportsbase64encbslibcachemcheckmatecliclustercodacolorspacecommonmarkcpp11data.tabledeSolvedigestdplyrevaluatefarverfastmapfontawesomeforeignFormulafsgenericsggplot2gluegridExtragtablehighrHmischtmlTablehtmltoolshtmlwidgetshttpuvisobandjquerylibjsonlitekm.ciknitrlabelinglaterlatticelifecyclemagrittrMatrixmemoisemimemvtnormnnetotelpillarpkgconfigpomppromisesr2d3R6rappdirsRColorBrewerRcpprlangrmarkdownrpartrstudioapiS7sassscalesshinysourcetoolsstringistringrsurvivaltibbletidyselecttinytexutf8vctrsviridisLitewithrxfunxtableyaml

Code and figures for 'DTAT should supersede MTD' v1

David C. Norris [email protected]

Rendered fromdtat.Rmdusingknitr::rmarkdownon May 20 2026.

Last update: 2023-03-29
Started: 2023-03-29

Designing a 3+3/PC trial

David C. Norris

Rendered fromDesigning-33PC.Rmdusingknitr::rmarkdownon May 20 2026.

Last update: 2020-06-14
Started: 2019-02-18