Package: DTAT 0.3-7

DTAT: Dose Titration Algorithm Tuning

Dose Titration Algorithm Tuning (DTAT) is a methodologic framework allowing dose individualization to be conceived as a continuous learning process that begins in early-phase clinical trials and continues throughout drug development, on into clinical practice. This package includes code that researchers may use to reproduce or extend key results of the DTAT research programme, plus tools for trialists to design and simulate a '3+3/PC' dose-finding study. Please see Norris (2017a) <doi:10.12688/f1000research.10624.3> and Norris (2017c) <doi:10.1101/240846>.

Authors:David C. Norris [aut, cre]

DTAT_0.3-7.tar.gz
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DTAT_0.3-7.tgz(r-4.4-any)DTAT_0.3-7.tgz(r-4.3-any)
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DTAT.pdf |DTAT.html✨
DTAT/json (API)

# Install 'DTAT' in R:
install.packages('DTAT', repos = c('https://dcnorris.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Datasets:
  • de.bioRxiv.240846 - Simulated '3+3/PC' dose-titration study from bioRxiv paper no. 240846
  • dtat1000 - Precomputed neutrophil-guided chemotherapy dose titration for 1000 simulated subjects.

On CRAN:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

2.90 score 20 scripts 336 downloads 2 mentions 11 exports 84 dependencies

Last updated 6 months agofrom:15c3359875. Checks:OK: 1 WARNING: 6. Indexed: yes.

TargetResultDate
Doc / VignettesOKNov 21 2024
R-4.5-winWARNINGNov 21 2024
R-4.5-linuxWARNINGNov 21 2024
R-4.4-winWARNINGNov 21 2024
R-4.4-macWARNINGNov 21 2024
R-4.3-winWARNINGNov 21 2024
R-4.3-macWARNINGNov 21 2024

Exports:as_d3_datadose.survfitdose.survivalds.curvenewton.raphsonOnoue.FribergplotrunDTATappsimtitratetitration

Dependencies:backportsbase64encbslibcachemcheckmatecliclustercodacolorspacecommonmarkcrayondata.tabledeSolvedigestdplyrevaluatefansifarverfastmapfontawesomeforeignFormulafsgenericsggplot2gluegridExtragtablehighrHmischtmlTablehtmltoolshtmlwidgetshttpuvisobandjquerylibjsonlitekm.ciknitrlabelinglaterlatticelifecyclemagrittrMASSMatrixmemoisemgcvmimemunsellmvtnormnlmennetpillarpkgconfigpomppromisesr2d3R6rappdirsRColorBrewerRcpprlangrmarkdownrpartrstudioapisassscalesshinysourcetoolsstringistringrsurvivaltibbletidyselecttinytexutf8vctrsviridisviridisLitewithrxfunxtableyaml

Code and figures for 'DTAT should supersede MTD' v1

David C. Norris [email protected]

Rendered fromdtat.Rmdusingknitr::rmarkdownon Nov 21 2024.

Last update: 2023-03-29
Started: 2023-03-29

Designing a 3+3/PC trial

David C. Norris

Rendered fromDesigning-33PC.Rmdusingknitr::rmarkdownon Nov 21 2024.

Last update: 2020-06-14
Started: 2019-02-18