Pharmacokinetic model | Myelosuppression model | Simulated population (inter-individual heterogeneity) | PK/PD simulation model | Adaptive dosing based on a simple Newton-Raphson heuristic | Linearize dynamics | Would day-7 ANC suffice as a proxy for nadir? | Simulated dose titration in 25 study subjects | SessionInfo

Precautionary Coherence and the '3+3/PC' Design | Optimal-Dose Heterogeneity | Precautionary Coherence and Dose Ranging | Precautionary Coherence | Dose Ranging in General | 3+3/PC as a Dose Ranging Design | Dose Ranging in Our Example | Simulating your 3+3/PC Trial | Introduction to the Dose-Titration Diagram | 3+3/PC Rules | An Interactive 3+3/PC Design & Simulation App | References